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トマトから脂肪肝、血中中性脂肪改善に有効な健康成分

 河田照雄 農学研究科教授(生理化学研究ユニット兼任)、金英一 同研究員らの研究グループは、柴田大輔 財団法人かずさDNA研究所部長(生存圏研究所客員教授)、日本デルモンテ株式会社、千葉県農林総合研究センターとの共同研究で、脂肪肝や高中性脂肪血症などの脂質代謝異常の改善に有効な新規成分13-oxo-9,11-octadecadienoic acid (13-oxo-ODA) をトマトから見出し、肥満マウスにおいて顕著な改善効果が得られることを確認しました。本研究成果は、米国オンライン科学誌PLoS ONEにて発表されます(日本時間2月10日)。
京都大学 http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/120210_1.htm

PLoS ONE より引用
Abstract Top
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis.